Efficacy of local inhibition of procoagulant activity associated with small-diameter prosthetic vascular grafts
نویسندگان
چکیده
منابع مشابه
Tissue engineering of small diameter vascular grafts.
Tissue engineering, using either polymer or biological based scaffolds, represents the newest approach to overcoming limitations of small diameter prosthetic vascular grafts. Their disadvantages include thromboembolism and thrombosis, anticoagulant related haemorrhage, compliance mismatch, neointimal hyperplasia, as well as aneurysm formation. This current review represents an overview about pr...
متن کاملModular Small Diameter Vascular Grafts with Bioactive Functionalities
We report the fabrication of a novel type of artificial small diameter blood vessels, termed biomimetic tissue-engineered blood vessels (bTEBV), with a modular composition. They are composed of a hydrogel scaffold consisting of two negatively charged natural polymers, alginate and a modified chitosan, N,O-carboxymethyl chitosan (N,O-CMC). Into this biologically inert scaffold two biofunctionall...
متن کاملTissue engineering of recellularized small-diameter vascular grafts.
A tissue-engineered small-diameter arterial graft would be of benefit to patients requiring vascular reconstructive procedures. Our objective was to produce a tissue-engineered vascular graft with a high patency rate that could withstand arterial pressures. Rat arteries were acellularized with a series of detergent solutions, recellularized by incubation with a primary culture of endothelial ce...
متن کاملAntithrombogenic modification of small-diameter microfibrous vascular grafts.
OBJECTIVE To develop small-diameter vascular grafts with a microstructure similar to native matrix fibers and with chemically modified microfibers to prevent thrombosis. METHODS AND RESULTS Microfibrous vascular grafts (1-mm internal diameter) were fabricated by electrospinning, and hirudin was conjugated to the poly (L-lactic acid) microfibers through an intermediate linker of poly(ethylene ...
متن کاملDevelopment of Novel, Bioresorbable, Small-Diameter Electrospun Vascular Grafts
This study proposes a production method capable of producing vascular grafts from fully synthetic, resorbable polymers that both meet basic minimum mechanical requirements for potential vascular grafts, and have a compliance similar to that of the intended vasculature being replaced. All of the electrospun vascular grafts in this work meet the minimum mechanical requirements for compliance, bur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 1996
ISSN: 0741-5214
DOI: 10.1016/s0741-5214(96)70078-2